Hey, I'm

Narges Rezaie

Post-doc fellow researcher at UC Irvine in Mortazavi Lab Bioinformatics Computational Biologist Pacakge/Software Developement Data Analyst

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About

Let me introduce myself.

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I am a Postdoc at the University of California, Irvine in Mathematical, Computational System Biology program (MCSB) in the Mortazavi lab.
I Graduated from Sharif University of Technology in 2018 with a B.S. in Information Technology, Computer Engineering. Coming from computational background, I'm mostly analysing different type of data inclusing bulk and single-cell RNA-seq data and developing software/pipeline.
My lab is part of a NIA Consortium to build better late-onset Alzheimer’s Disease models in mouse and I'm mostly in charge of developing and implementing standardized data acquisition and data analysis protocols for the UCI model-AD data such as single-cell transcriptomics in these new models.
My lab is also part of a ENCODE Consortium and IGVF (Impact of Genomic Variation on Function) Consortium to build better late-onset Alzheimer’s Disease models in mouse and I'm mostly in charge of developing and implementing data analysis protocols as well as devloping software/packages especially for short bulk and single-cell transcriptomics.
Out of work, I love to spend time with our kittens, go camping, hike and cook presion dishes.

Profile

Selected Skills

For more informations download my CV.

  • 100%
    Python
  • 100%
    R
  • 100%
    Java
  • 85%
    shinyapps
  • 85%
    Flask

More of my experiences.

Education

Director PhD

2019-2024

University of California, Irvine

In Mathematical, Computational System Biology program (MCSB)
Gpa: 3.98/4

Bachelor's Degree

2014-2018

Sharif university of technology

In Information Technology, Computer Engineering
Gpa: 17.07/20

Diploma

2010-2014

Farzanegan Amin high school, National Organization for Development of Exceptional Talents(NODET)

In Mathematics
Gpa: 19.90/20

Research Experience

Psot-doc/Research Assistant

Mortazavi Lab

2019-present

Model AD

We are part of a NIA Consortium to build better late-onset Alzheimer’s Disease models in mouse. I mostly invovle in bioinformatics parts as well as single-cell transcriptomics in these new models.

Gene Regulatory Networks

I'm trying to build models of gene regulatory networks using either bulk or single-cell RNA-seq, and ATAC-seq in human, rodents, and other vertebrates in order to discover how the logic of development is encoded in the genome.

ENCODE Consortium

We are part of a ENCODE Consortium to build and analyse various type of data including short and long RNA-seq. As a member of this Consortium, I'm intersted in analysing them to understand how gene expression and chromatin states change during time.

Research Assistant

Bioinformatics and Computational Biology Lab

2016 - 2018

Statistical Analysis of Clinical Data - Golestan Cohort

Available in Github

Designing a statistical model to predict risk of cardiovascular disease

Publication

2022

MaxHiC: A robust background correction model to identify biologically relevant chromatin interactions in Hi-C and capture Hi-C experiments

Hamid Alinejad-Rokny, Rassa Ghavami Modegh, Hamid R Rabiee, Ehsan Ramezani Sarbandi, Narges Rezaie, Kin Tung Tam, Alistair RR Forrest

Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer

Narges Rezaie, Masroor Bayati, Mehrab Hamidi, Maedeh Sadat Tahaei, Sadegh Khorasani, Nigel H Lovell, James Breen, Hamid R Rabiee, Hamid Alinejad-Rokny

A Trem2* R47H mouse model without cryptic splicing drives age-and disease-dependent tissue damage and synaptic loss in response to plaques

Kristine M Tran, Shimako Kawauchi, Enikö A Kramár, Narges Rezaie, Heidi Yahan Liang, Miguel Arreola, Celia Da Cunha, Jimmy Phan, Sherilyn Collins, Amber Walker, Jonathan Neumann, Giedre Milinkeviciute, Angela Gomez-Arboledas, Dominic I Javonillo, Katelynn Tran, Magdalena Gantuz, Stefania Forner, Vivek Swarup, Andrea J Tenner, Frank LaFerla, Marcelo A Wood, Ali Mortazavi, Grant R MacGregor, Kim N Green

Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's Disease

Dominic I Javonillo, Kristine M Tran, Jimmy Phan, Edna Hingco, Enikö A Kramár, Celia Da Cunha, Stefania Forner, Shimako Kawauchi, Giedre Milinkeviciute, Angela Gomez-Arboledas, Jonathan Neumann, Crystal E Banh, Michelle Huynh, Dina P Matheos, Narges Rezaie, Joshua A Alcantara, Ali Mortazavi, Marcelo A Wood, Andrea J Tenner, Grant R MacGregor, Kim N Green, Frank M LaFerla

2021

Bulk and single‐nucleus analysis of the 3xTgAD cortex and hippocampus transcriptome

Narges Rezaie, Gabriela Balderrama Gutierrez, Heidi Yahan Liang, Stefania Forner, Ali Mortazavi, MODEL AD

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

Stefania Forner, Shimako Kawauchi, Gabriela Balderrama-Gutierrez, Enikö A Kramár, Dina P Matheos, Jimmy Phan, Dominic I Javonillo, Kristine M Tran, Edna Hingco, Celia da Cunha, Narges Rezaie, Joshua A Alcantara, David Baglietto-Vargas, Camden Jansen, Jonathan Neumann, Marcelo A Wood, Grant R MacGregor, Ali Mortazavi, Andrea J Tenner, Frank M LaFerla, Kim N Green

Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tangles

Gabriela Balderrama-Gutierrez, Heidi Liang, Narges Rezaie, Klebea Carvalho, Stefania Forner, Dina Mattheos, Elisabeth Rebboah, Kim N Green, Andrea J Tenner, Frank LaFerla, Ali Mortazavi

2020

MaxHiC: robust estimation of chromatin interaction frequency in Hi-C and capture Hi-C experiments

Hamid Alinejad-Rokny, Rassa Ghavami Modegh, Hamid R Rabiee, Narges Rezaie, Kin Tung Tam, Alistair RR Forrest

Contact
Where to find me

2218 Biological Sciences III,
University of California Irvine,
Irvine, CA 92697-2300

Email Me At

nargesr@uci.edu

Call Me At

(949) 426-8112